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The Massive Next Big Thing National Genome ProjectsNov 2.The Third Hungarian NotationOct 0.Non coding portions of genome are found to play role in cancerSep 2.Microsoft initiatives treat cancer as a computing problemSep 1.Junk DNA tells mice and snakes how to grow a backboneSep 1.The Oncoming Double Disruption of Technology of New School Genomics Smidg.ION by Oxford NanoporeSep 0.Dr. Pellionisz comments on the 7 R D articles posted on Labor Day, 2.AndrasatPellioniszdotcomSep 0.Multiscale modeling of cellular epigenetic states stochasticity in molecular networks, chromatin folding in cell nuclei, and tissue pattern formation of cellsSep 0.Fractal Dimension of Tc 9.DTPA GSA Estimates Pathologic Liver Injury due to Chemotherapy in Liver Cancer PatientsSep 0.Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesotheliomaSep 0.Systems Medicine of Cancer Bringing Together Clinical Data and Nonlinear Dynamics of Genetic NetworksSep 0.ASXL2 promotes proliferation of breast cancer cells by linking ER to histone methylationSep 0.Researchers identify two proteins important for the demethylation of DNASep 0.Mathematical Modelling and Prediction of the Effect of Chemotherapy on Cancer CellsSep 0.Breast cancer researchers look beyond genes to identify more drivers of disease developmentAug 3.HPE Synergy Shows Promise And Progress With Early AdoptersAug 2.Illumina Can GRAIL Deal A Death Blow In The War Against CancerAug 1.Precision medicine Analytics, data science and EHRs in the new ageAug 1.Stanford Medicine, Google team up to harness power of data science for health careAug 0.Leroy Hood 2. 00.The Genome is a System needs some system theoryAug 0.What if Dawkins Selfish Gene would have been Selfish Fracto.GeneJul 2. 5 DNA pioneer James Watson The cancer moonshot is crap but there is still hopeJul 2.Science Cover Issue 2.July 2. 2 with Fractal folding of DNA and of ProteinsJul 2.CRISPR Immunotherapy aheadJul 2.Qatari genomes provide a reference for the Middle EastJul 1.CIA Chief Claims that Genome Editing May Be Used For Biological WarfareJul 1.Are Early Harbingers of Alzheimers Scattered Across the GenomeJul 0.Independence Day A 2.Apple as a teenager wants to make a yearly blood test to diagnose cancer and he just got 5.Silicon Valley VCs to pull it offJun 2.President Obama Hints He May Head to Silicon Valley for His Next JobJun 1.Is This the Biggest Threat Yet to IlluminaMay 2. 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What technique did you use to force. a recheck related question My updates never finish on a PC that last good check was 4 months ago. It is expected that our network will use two different update policies one for servers Servers and another one for workstations Workstations. Tip. The policy of using the WSUS server by its clients depends largely on the organizational structure of the Active Directory OU organization units and update installation rules in the company. In this article we will try to understand the basic principles of using AD policies to install Windows updates. First of all, you have to specify the rule of grouping the computers in the WSUS console targeting. By default, the computers in the WSUS console are distributed into groups manually by the server administrator server side targeting. It does not suit us, so we specify that the computers are to be distributed into groups using the client side targeting group policies or registry parameters. To do this, in the WSUS console click Options and open Computers. Change the value to Use Group Policy or registry settings on computers. Next we will configure WSUS clients via GPO. Open the Group Policy Management console and create two new group policies Server. WSUSPolicy and Workstation. WSUSPolicy. WSUS Group Policy for Windows servers. Lets start with the description of the server policy Server. WSUSPolicy. For group policy settings of Windows Update Services, see the following GPO section Computer Configuration Policies Administrative templates Windows Component Windows Update. In our environment, we suggest to use this policy to install WSUS updates to Windows servers. All the computers that fall under this policy are assumed to belong to the Servers group in the WSUS console. Besides, we want to disable the automatic installation of updates on the servers when they are received. A WSUS client should just download the available updates, display the corresponding notification in the system tray and wait for administrator approval to begin the installation. Thus we guarantee that the productive servers will not automatically install updates and restart without the permission of the administrator usually these actions are performed by the system administrator as part of the planned routine works. To implement such scheme, lets set the following policies Configure Automatic Updates Enable. Auto download and notify for install client automatically downloads new updates and notifies you about them. Specify Intranet Microsoft update service location Enable. Set the intranet update service for detecting updates http wsus. Set the intranet statistics server http wsus. WSUS server and the statistics server usually they are the sameNo auto restart with logged on users for scheduled automatic updates installations Enable disable automatic restart if the user session is open. Enable client side targeting Enable. Target group name for this computer Servers inthe WSUS console, referclientstothe group of Servers. Note. When you configure update policies, we recommend you to get acquainted with all the settings that are available in each option of Windows Update section, and set the parameters suitable for your infrastructure and organization. WSUS Group Policies for Workstations. We assume that in contrast to the server policy, updates to the client workstations are installed automatically at night after receiving the updates. After the updates are installed, the PCs are restarted automatically having notified the user in 5 minutes. In this policy, we specify Allow Automatic Updates immediate installation Disabled the immediate installation of updates after they are received is disabled. Allow non administrators to receive update notifications Enabled display notifications of the new updates to non administrators and allows to install them manually. Configure Automatic Updates Enabled. Configure automatic updating 4 Auto download and schedule the install. Scheduled install day 0 Every day. Scheduled install time 0. Target group name for this computer Workstations refers clients to the group Workstations in the WSUS console. No auto restart with logged on users for scheduled automatic updates installations Disabled Specify Intranet Microsoft update service location Enable. Set the intranet update service for detecting updates http wsus. Set the intranet statistics server http wsus. WSUS server. Tip. To let the computers in the company have all available patches installed, both policies can be configured so that the update service wuauserv is forced to start on the client. To do it, under Computer Configuration Policies Windows Settings Security Settings System Services find Windows Update and set it to start automatically Automatic. Assign the WSUS Policies to Active Directory OUThe next step is to assign the created policies to the corresponding Active Directory containers OU. In our example OU structure is extremely simple there are two containers Servers it contains all servers of the company, as well as domain controllers and WKS Workstations user computers. Tip. We consider only a fairly simple option of binding the WSUS policies to clients. In real world, it is possible to bind a single WSUS policy to all domain computers a GPO is assigned to the domain root, distribute different computers between different OUs like in our example, in distributed networks its worth to bind different WSUS servers to the AD sites, or to assign a GPO based on the WMI filters, or even combine these methods. To assign the policy to the OU, click the correct OU in the Group Policy Management Console, click Link an Existing GPO, and then check the appropriate policy. Tip. Dont forget about the OU Domain Controllers. In most cases the WSUS Server policy should be bound to this container. You have to assign Workstation. WSUSPolicy to the AD container with the name WKS in the same way. Now you only have to update group policies on the clients In some time it depends on the number of updates and bandwidth to the WSUS server check if there is a pop up notification of the new updates in the tray. Clients the clients name, an IP, an OS, patch percentage and the date of the last status update should appear in the corresponding groups in the WSUS console. Note. If the updates do not appear on the client, its recommended to study the log of Windows Update service on the client that has faced the problem C WindowsWindows. Update. log. The downloaded updates are saved to C WindowsSoftware. DistributionDownload. You can try to run an immediate poll of the WSUS server by its client Also, sometimes you have to force the client to re register on the WSUS server 1. Authorization. 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The instructions for upgrading My.SQL from 5. 1 to 5.Linux see in the KB article Warning Direct upgrade from My.SQL 5. 1 to My. SQL 5.Maria. DB 1. 0. 2 is not fully supported by Plesk.Note Upgrade can be performed in a command line interface with the instructions below at your own risk.This task is supposed to be performed by a system administrator.Dump Mysql Database Command Line Windows Key' title='Dump Mysql Database Command Line Windows Key' />First of all, connect to the server via SSH.For Ubuntu 1. 2. 0.Debian 7 Ubuntu 1.My. SQL 5. 5 by default.Create a full server backup and a server snapshot.Create a backup of etcmysqlmy.Add the My. SQL APT Repository Go to the download page for the My.SQL APT repository at http dev.Select and download a release package for your platform wget http dev.Install the downloaded release package dpkg i mysql apt config0.During the installation of the package, you will be asked to choose the versions of the My.SQL server and other components that you want to install.If you are not sure which version to choose, do not change the default options selected for you.You can also choose none if you do not want a particular component to be installed.After making the choices for all components, choose Apply to finish the configuration and installation of the release package.Update package information from the My.SQL APT repository apt get update.Upgrade My. SQL apt get install mysql server Agree when prompted to update etcmysqlmy.Make sure that mysql community libs compat package is installed.Install if it is missing.In Plesk go to Tools Settings Server Components and click Refresh.Upgrade My. SQL databases MYSQLPWDcat etcpsa.More information available in My.SQL documentation at http dev.For Cent. OS 6 Stop the My.SQL service service mysqld stop.Create a backup of databases cp a varlibmysql varlibmysqlbackup.Disable Atomic repository, if it is enabled vi etcyum.Install the My. SQL community repository yum install http dev.Select a My. SQL version vi etcyum.Install My. SQL packages yum update mysql.If update of mysql package ends with Nothing to do message, make sure that mysql packages are not added to excludes in yum.Type y if this message appears CONFIGTEXT warning rpmtsHdr.From. Fdno Header V3 DSASHA1 Signature, key ID 5.NOKEYRetrieving key from file etcpkirpm gpgRPM GPG KEY mysql.Importing GPG key 0x.E1. F5 Userid My.SQL Release Engineering lt mysql buildoss.Package mysql. 57 community release el.From etcpkirpm gpgRPM GPG KEY mysql.Is this ok yN Start the My.SQL service service mysqld start.If the service does not start, check the following article My.SQL fails to start mysql.Upgrade My. SQL databases MYSQLPWDcat etcpsa.Restart mysql service service mysqld restart For Cent.OS 7 Cent. OS 7 is shipped with Maria.DB. Maria. DB 1. 0.My. SQL 5. 5 5. 7.Create a backup of all databases with the following command MYSQLPWDcat etcpsa.Stop the Maria. DB service service mariadb stop.Remove additional packages like mariadb bench rpm e mariadb bench.Copy a databases directory in a separate folder like this for backup purposes also cp a varlibmysql varlibmysqlbakup.Add the Maria. DB repository cat etcyum.Maria. DB1. 0. 1.Maria. DBbaseurl http yum.RPM GPG KEY Maria.DBgpgcheck 1. Perform an upgrade with yum install mariadb.Start the Maria. DB service service mariadb start.Execute this command to update the package version inside Plesk plesk sbin packagemng sdf.Note After an upgrade to 1. Driver Robot V2 5 4 2 Incl Serial Serial Serial . It can be removed rm etcinit.For Debian 8 Debian 8 is basically shipped with Maria.DB. Maria. DB 1. 0.My. SQL 5. 55. 65.Backup all existing databases using the KB article How to backuprestore a Plesk database dump and follow instructions on Maria.DB site to update it https mariadb.Execute this command to update package version inside Plesk plesk sbin packagemng sdf.Additional Information.Descargar My. SQL 5.File. Hippo. com.Ttulo. My. SQL 5.Nombre de fichero.Tamao de fichero.MB. 3. 3,6. 52,7.Requisitos. Windows 9x 2.XP Vista Windows 7 Windows 8 Windows 1.Windows 1. 0 6. 4 bit.Idiomas. Mltiples idiomas.Licencia. Open Source.Fecha aadida. 1. MD5 Checksum.E1. D5. 84. 5AC1.B4. DB3. C5. 77. 57.E7. 71. 1. Compilation Notes Windows builds now use the default runtime libraries builds use the MD flag.CMake support was added for compiling with Developer Studio 1.Configuration Notes My.SQL failed to compile if DENABLEDEBUGSYNCOFF AND DWITHDEBUGON were both given.The ENABLEDEBUGSYNC option has been removed and enabling WITHDEBUG enables Debug Sync.Packaging Notes Changes in RPM package structure require a larger set of packages to be removed to install My.SQL Server cleanly.To avoid potential race conditions, Debian packages now use the GNU install utility rather than a combination of mkdir, touch, and chown.CMake generated packaging for DebianUbuntu packages was refactored for improved maintainability.The change includes updated logic for correctly replacing native distribution packaging in Debian and Ubuntu.Reminder My. SQL 5.Microsoft Visual C 2.Redistributable Package to run on Windows platforms.Users should make sure the package has been installed on the system before starting the server.The package is available at the Microsoft Download Center.Security Notes The linked Open.SSL library for the My.SQL Commercial Server has been updated to version 1.For a description of issues fixed in this version,This change does not affect the Oracle produced My.SQL Community build of My.SQL Server, which uses the ya.SSL library instead.The mysqloptions C API function now supports a MYSQLOPTSSLMODE option.The only permitted option value is SSLMODEREQUIRED, to require a secure connection to the server.It causes mysqlrealconnect to fail if an encrypted connection cannot be obtained, without falling back to an unencrypted connection.Thus, mysqlrealconnect returns an error if the server does not support SSL or the client is not configured to use SSL.The clientserver exchange terminates immediately after the initial server packet has been received if the server indicates that it does not support SSL.To require an encrypted connection in My.SQL 5. 6, the standard My.SQL client programs call mysqloptions to set MYSQLOPTSSLMODE if the ssl modeREQUIRED command line option was specified.Third party applications that must be able to require encrypted connections can use the same technique.For details, see mysqlsslset.The minor C API version number was not incremented for this change.Application programs compiled for My.SQL 5. 6 that require MYSQLOPTSSLMODE may fail to operate properly if the dynamic loader provides an older client library without MYSQLOPTSSLMODE.Such applications must be written to handle this possibility by checking whether the mysqloptions call succeeds or fails.Thread Pool Notes To improve threadpool plugin performance, connection authentication and initialization have been moved from the acceptor thread to the thread pool worker threads that handle client connections.This enables the acceptor thread to handle new connections at a higher rate with reduced latency.The INFORMATIONSCHEMA TPTHREADGROUPSTATE table now contains a CONNECTTHREADCOUNT column that indicates the number of threads that are processing or waiting to process connection initialization and authentication.There can be a maximum of four connection threads per thread group these threads expire after a period of inactivity.Functionality Added or Changed Replication When a negative or fractional timeout parameter was supplied to WAITUNTILSQLTHREADAFTERGTIDS, the server behaved in unexpected ways.With this fix A fractional timeout value is read as is, with no round off.A negative timeout value is rejected with an error if the server is on a strict SQL mode if the server is not on a strict SQL mode, the value makes the function return NULL immediately without any waiting and then issue a warning.The performance of UTF 8 binary collations was improved.Consistency and maintainability of DebianUbuntu packaging maintainer scripts was improved.Bugs Fixed Inno. DB The restriction that required the first undo tablespace to use space ID 1 was removed.The first undo tablespace may now be assigned a space ID other than 1.Space ID values for undo tablespaces are still assigned in a consecutive sequence.Inno. DB Compiling the server without the Performance Schema caused a build failure.Inno. DB The file handle type name for Inno.DB file IO Performance Schema instrumentation was changed from ospfsfilet to pfsosfilet.Inno. DB A server exit on restart was caused by missing mythreadinit and mythreadexit functions for background threads that initialize the stmythreadvar structure.Inno. DB A memcached read operation with a non default read batch size configuration resulted in a server exit.Inno. DB Performance Schema instrumentation for Inno.DB file IO was disabled on Windows.Inno. DB The rowsearchmvcc function unnecessarily traversed the entire table for a range query, which occurred when the record was not in the transaction read view.Replication When using a multi threaded slave slaveparallelworkers greater than 0 the value of SecondsBehindMaster was incorrect when rotating a relay log.SQL statements written to the dump output.Client preauthorization by the server was missing a length check for a length encoded string.For DebianUbuntu packages, user defined collation files could be overwritten during My.SQL upgrades. Charset files are now marked as conffiles so that user customizations generate a prompt during upgrades whether to overwrite them.For CREATE TABLE statements that specified the table name with a database qualifier and included a DATA DIRECTORY or INDEX DIRECTORY option, an error occurred if there was no default database.Starting the server with performanceschemadigestssize1 caused an abnormal exit.FIFO. mysqldsafe could fail if the datadir option value ended with a character.A recent change to mysqldsafe caused the mysql.The fix for Bug 7.Performance Schema is enabled.The connectioncontrol plugin failed to compile if the Performance Schema was disabled.For System V init scripts for RPMs, the mysqld option file section was being ignored for some options, such as pid file.Init scripts failed to launch mysqldsafe if a non default base directory was used.Semicolon characters within or between statements could cause distinct digests to be generated from identical statements.For a client linked against libmysqlclient, invalid memory access could occur during use of prepared statements.The fix for Bug 2.My. SQL server to no longer include the mysqld path.Executing a stored procedure containing a query that accessed a view could allocate memory that was not freed until the session ended.A query could produce incorrect results if the WHERE clause contained a dependent subquery, the table had a secondary index on the columns in the select list followed by the columns in the subquery, and GROUP BY or DISTINCT permitted the query to use a Loose Index Scan.Creation of a My.ISAM temporary table during query processing could fail if the key length in the query was greater than the maximum My.ISAM key length, resulting in a server exit.The Debug. Print.Test and Debug. Print.Death. Test unit tests did not handle divide by zero testing properly on the Aarch.Thanks to Alexey Kopytov for the patch.Changes made to mysqldsafe in recent My.SQL releases require the ledir, mysqld, mysqld version options to be specified on the command line they can no longer be specified in option files.This could cause failure of init scripts that invoke mysqldsafe.Such scripts now pass the value of the MYSQLDOPTS environment variable as the first command line argument to mysqldsafe, with the value set to such command line only mysqldsafe option values as may be required.On platforms that use etcsysconfigmysqld, the MYSQLDOPTS value can be set in that file with a line such as this MYSQLDOPTS ledirmysqldledir mysqldmywrapper The value of MYSQLDOPTS can also include mysqld options for mysqldsafe to pass to mysqld. 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